Effect of rosiglitazone and ramipril on -cell function in people with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG): the DREAM Trial. Running title: Rosiglitazone, ramipril and -cell function
نویسندگان
چکیده
1. Department of Nutritional Sciences, University of Toronto 2. Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada 3. Division of Endocrinology, Department of Medicine, University of Toronto 4. Division of Endocrinology and Metabolism and the Population Health Research Institute, Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
منابع مشابه
Effect of Rosiglitazone and Ramipril on β-Cell Function in People With Impaired Glucose Tolerance or Impaired Fasting Glucose
OBJECTIVE The objective of this study was to determine the degree to which ramipril and/or rosiglitazone changed beta-cell function over time among individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) who participated in the Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication (DREAM) Trial, which evaluated whether ramipril and/or rosiglita...
متن کاملEffect of ramipril and of rosiglitazone on carotid intima-media thickness in people with impaired glucose tolerance or impaired fasting glucose: STARR (STudy of Atherosclerosis with Ramipril and Rosiglitazone).
OBJECTIVES The aim of this study was to evaluate effects of the angiotensin-converting enzyme (ACE) inhibitor ramipril and the thiazolidinedione (TZD) rosiglitazone on carotid intima-media thickness (CIMT) in people with impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG). BACKGROUND People with IGT and/or IFG are at increased long-term risk for cardiovascular disease. Effe...
متن کاملDREAM study and its impact on India.
P denotes a stage prior to clinical onset of diabetes. This includes two conditions namely Impaired Glucose Tolerance (IGT) and Impaired Fasting Glucose (IFG).1,2 Over one third of subjects with prediabetes develop diabetes within five years.3 Individuals with pre-diabetes are not only at high risk for developing diabetes but are also considered to be at increased risk for coronary artery disea...
متن کاملEffect of ramipril on the incidence of diabetes (DREAM Study).
BACKGROUND Previous studies have suggested that blockade of the renin-angiotensin system may prevent diabetes in people with cardiovascular disease or hypertension. METHODS In a double-blind, randomized clinical trial with a 2-by-2 factorial design, we randomly assigned 5269 participants without cardiovascular disease but with impaired fasting glucose levels (after an 8-hour fast) or impaired...
متن کاملPoint: If it is important to prevent type 2 diabetes, it is important to consider all proven therapies within a comprehensive approach.
T ype 2 diabetes is a common metabolic disease that is defined on the basis of glucose levels above specific thresholds. Individuals with type 2 diabetes are at high risk of blindness, renal failure, amputation, cardiovascular disease, premature death, dementia, and a variety of other chronic diseases and lifethreatening events. However, unlike other risk factors for future events (e.g., hyperl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009